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HelpEpic Code LAB3563 Iodine, Serum
Additional Codes
Mayo Code: IOD
Epic Code: LAB 3563
Interface code: 55034
Cerner code: 7086
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Determining iodine overload using serum specimens
Monitoring iodine levels in individuals taking iodine-containing drugs
Specimen Type
SerumSpecimen Required
Patient Preparation:
1. Disinfectants (such as Betadine) that contain iodine should not be used during venipuncture.
2. High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Supplies:
-Metal Free B-D Tube (No Additive), 6 mL (T184)
-Metal Free Specimen Vial (T173)
Collection Container/Tube: Plain, royal blue-top Vacutainer plastic trace element blood collection tube
Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial
Specimen Volume: 1 mL
Collection Instructions:
1. Allow specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.
2. Remove the stopper. Carefully pour specimen into Mayo metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.
3. See Trace Metals Analysis Specimen Collection and Transport for complete instructions.
COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.
Special Instructions
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Ambient | 21 days | ||
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Day(s) Performed
Tuesday, Friday
Reference Values
40-92 ng/mL
Clinical Information
Iodine is an essential element required for thyroid hormone production. The measurement of iodine serves as an index of adequate dietary iodine intake and iodine overload, particularly from iodine-containing drugs, such as amiodarone.
Cautions
There are no known analytical interferences with this procedure.
Administration of iodine-containing contrast media will yield elevated results.
Interpretation
Values between 80 ng/mL and 250 ng/mL have been reported to indicate hyperthyroidism.
Values above 250 ng/mL may indicate iodine overload.
Reporting Name
Iodine, SMethod Name
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Method Description
The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)
CPT Code Information
83789
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IOD | Iodine, S | 2494-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81574 | Iodine, S | 2494-3 |
Report Available
1 to 4 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Clinical Reference
1. Allain P, Berre S, Krari N, et al. Use of plasma iodine assay for diagnosing thyroid disorders. J Clin Pathol. 1993;46(5):453-455.
2. Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023
3. Leung AM, Braverman LE, Consequences of excess iodine. Nat Rev Endocrinol. 2014;10(3):136-142. doi: 10.1038/nrendo.2013.251
4. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry: Toxicological Profile for Iodine. HHS; 2004. Accessed June 29, 2023. Available at www.atsdr.cdc.gov/ToxProfiles/tp158.pdf
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