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Epic Code LAB1230099 Allergen Specific IgE

Test Name Alias

allergen | ImmunoCAP | Allergen Specific IgE |RAST| Allergy | HISLAB60 | 6787

Interface Order Alias


Clinical Information

All allergens are reported down to a cutoff level of 0.10 kU/L. The significance of allergen specific IgE levels between 0.10 and 0.35 kU/L remains undefined. Cumulative levels of multiple allergen specific IgE antibodies may have an additive effect in producing clinical symptoms.

Individual allergen specific IgE antibody levels may not always correlate with severity of clinical symptoms. Results must be interpreted in the context of the clinical history and the patient’s symptom presentation. Quantitative IgE levels can serve to guide overall disease management by targeted trigger exposure reduction to identified allergens.

Allergens with a high risk of anaphylaxis (egg, milk, soy, wheat, nuts, seafood, kiwi fruit, latex, insect venoms, drugs) are reported with a reference range of <0.10 kU/L, lower than the <0.35 kU/L reference range used for other routine allergens. IgE antibody levels to these allergens less than 0.10 kU/L do not exclude the possibility of an anaphylactic reaction to the allergen involved, since in vitro assays are indicators of previous sensitization rather than predictors of future response. IgE antibody levels must be interpreted in the context of the clinical history of the patient and the reaction history involved.

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL per 15 allergens

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok: Yes

Microtainer acceptable: Yes

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed within 2 hours – See Processing Instructions.
  • One full tube per 15 allergens

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: No

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.

Transport Temperature: Refrigerate

Rejection Criteria

Quantity not sufficient (QNS)
Specimen not centrifuged within 2 hours

Specimen Stability

Ambient: 12 hours

Refrigerate : 7 days

Frozen: aliquot serum for longer storage

Laboratory Retention: 30 days (frozen)

Test Frequency

Available Monday through Friday, usual TAT 1-3 days.

Reference Range

<0.35 kU/L

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI


ImmunoCAP® System Fluorescence Enzyme Immunoassay (FEIA)

CDM Code


Epic Test ID



Allergen Specific IgE Interp: 50622-0

Mayo Access Code


Additional Information

Lab Staff:
For 1 allergen: 0.3mL serum
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25mL dead space

Reviewed Date