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Test Code LAB1230099 Allergen Specific IgE

Test Name Alias

allergen | ImmunoCAP | Allergen Specific IgE |RAST| Allergy | HISLAB60 | 6787

Clinical Information

Individual allergen specific IgE antibody levels may not always correlate with severity of clinical symptoms. Results must be interpreted in the context of the clinical history and the patient’s symptom presentation. Quantitative IgE levels can serve to guide overall disease management by targeted trigger exposure reduction to identified allergens.

All allergens are reported down to a cutoff level of 0.10 kU/L. The significance of allergen specific IgE levels between 0.10 and 0.35 kU/L remains undefined. Cumulative levels of multiple allergen specific IgE antibodies may have an additive effect in producing clinical symptoms.

Allergens with a high risk of anaphylaxis (egg, milk, soy, wheat, nuts, seafood, kiwi fruit, latex, insect venoms, drugs) are reported with a reference range of ≤0.09 kU/L, lower than the ≤0.34 kU/L reference range used for other routine allergens. IgE antibody levels to these allergens less than 0.10 kU/L do not exclude the possibility of an anaphylactic reaction to the allergen involved, since in vitro assays are indicators of previous sensitization rather than predictors of future response. IgE antibody levels must be interpreted in the context of the clinical history of the patient and the reaction history involved.

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL per 15 allergens

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok: Yes

Microtainer acceptable: Yes

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed within 2 hours – See Processing Instructions.
  • One full tube per 15 allergens

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: No

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.

Transport Temperature: Refrigerate

Rejection Criteria

Quantity not sufficient (QNS)
Specimen not centrifuged within 2 hours

Specimen Stability

Ambient: 12 hours

Refrigerate : 7 days

Frozen: aliquot serum for longer storage

Laboratory Retention: 30 days (frozen)

Test Frequency

Available three times per week, usual TAT 3-5 days.

Reference Range

≤ 0.34 kU/L

Performing Department

IMMUNOCHEMISTRY

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI

Methodology

ImmunoCAP® System Fluorescence Enzyme Immunoassay (FEIA)

CPT

86003

CDM Code

4026787

Epic Test ID

1230100346

Interface Order Alias

10573

Mayo Access Code

SHO6787

LOINC

Allergen Specific IgE Interp: 50622-0

Additional Information

Lab Staff:
For 1 allergen: 0.3mL serum
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25mL dead space
1 tube per panel

Reviewed Date

7/18/2017