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Test Code LAB1230378 Noninvasive Prenatal Screening for Fetal Aneuploidy

Important Note

UPDATED 6/3/2020 – This test has been put on hold until further notice. Spectrum Health Laboratory will continue to forward orders for Noninvasive Prenatal Screening to Natera to perform the testing.

Test Name Alias

NIPS | NIPT | Panorama

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Clinical Information

Non-invasive prenatal test (NIPT) is performed on maternal blood to screen for specific chromosomal aneuploidies in fetus in chromosomes 13, 18, 21, X and Y. 

Collection Instructions

Specimen Collection: Blood


Container(s): Need two tubes of 10 mL Streck Tubes

Preferred Volume to Collect: 20 mL

Minimum Volume to Collect: 20 mL

Neonate Volume to Collect: N/A

Capillary collect ok? No

Microtainer acceptable: No

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Whole Blood


Centrifuge/Spin: No

Aliquot: No


Transport Temperature: Ambient

Lab Staff Instructions

Send to ATL

Specimen Stability

Ambient: 72 Hours

Refrigerate: Not Applicable

Frozen: Not Applicable

Laboratory Retention: 3 Days

Test Frequency

  • Performed Twice Weekly
  • Average Turn Around Time: 7-10 Days

Reference Range

An interpretive report will be provided.

Performing Department


Performing Department Laboratory Location

Spectrum Health Regional Laboratory (SHRL LC) - Advanced Technology Laboratory (ATL), Grand Rapids, MI


This non-invasive prenatal test (NIPT) is performed on maternal blood to screen for specific chromosomal aneuploidies in fetus. Cell-free DNA isolated from maternal blood, which contains maternal and placental DNA, is amplified at >13,300 specific loci using a targeted PCR assay and sequenced on Illumina NextSeq instrument. Sequence data is analyzed using Natera’s Constellation software to estimate fetal fraction, and to determine the fetal copy number for chromosomes 13, 18, 21, X and Y, thereby identifying the risk of whole chromosome abnormalities at these locations. Genetic interpretation services are performed by Natera CLIA lab (CLIA# 05D1082992). Conditions screened include trisomy 13 (Patau syndrome), trisomy 18 (Edwards syndrome), trisomy 21 (Down syndrome), and monosomy X (Turner syndrome).



CDM Code


Epic Test ID


Interface Order Alias


Additional Information

Form: NIPS Consent

Reviewed Date