Epic Code LAB1230524 P1NP (Procollagen 1 Intact N-Terminal Propeptide)
Test Name Alias
P1NP | PINP | Procollagen peptide | P1NP, Intact
Interface Order Alias
1230524
Clinical Information
The amino-terminal propeptide of type 1 procollagen (P1NP) is probably the most specific and sensitive marker for monitoring the efficacy of osteoporosis therapy with anabolic agents, but it is also one of the best bone turnover markers for monitoring the efficacy of antiresorptive therapy.
Ordering Instructions
Procollagen 1 intact N-terminal (P1NP) values should not be used as a screening test for osteoporosis in the general population.
Icons & Photos
Collection Instructions
Specimen Recommendations
- There is diurnal variation of P1NP levels, with the values being higher at night.
- When serial measurements of P1NP are performed, specimens should be collected at the same time of the day.
- Fasting versus fed state may also cause variation in results. Therefore fasting sample is recommended.
- P1NP is metabolized in the liver. In individuals with severe liver disease, clearance from the circulation might be affected resulting in elevated P1NP levels.
Specimen Collection: Blood
Container(s): Gold Top (Serum Separator-SST Gel)
Preferred Volume to Collect: 5.0 mL
Minimum Volume to Collect: 2.0 mL
Neonate Volume to Collect: n/a
Capillary collect ok? Yes
Microtainer acceptable: Yes
Collection Instructions:
- Fasting specimen is preferred, but not required.
- After collection, gently invert gold tube 8 - 10 times to mix clot activator with blood.
- Specimen should be processed immediately - see processing instructions
Processing Instructions (Laboratory, Outpatient or Off-site collection)
Processed Specimen: Serum
Centrifuge/Spin: Yes
Aliquot: Yes
Processing Instructions:
- Allow blood to clot for 30 minutes in a vertical position and centrifuge promptly.
- Within 1 hour aliquot serum into a plastic transport tube and freeze immediately.
- +(1)S/PO/F
Transport Temperature: Frozen
Rejection Criteria
- Specimen not centrifuged promptly after collection
- Serum is not frozen
- Grossly hemolyzed specimen
Specimen Stability
Ambient: Not acceptable
Refrigerate: Not acceptable
Frozen: Aliquot serum and freeze for longer storage (7 days)
Laboratory Retention: 7 days
Test Frequency
Available Monday, Wednesday and Friday, usual turn-around time 2 - 3 days.
Reference Range
23 mcg/L to 83 mcg/L for male and female
Performing Department
IMMUNOCHEMISTRY
Performing Department Laboratory Location
Spectrum Health Regional Laboratory (SHRL BW), Grand Rapids, MI
Methodology
Chemiluminescence
CPT
83520
CDM Code
Currently unavailable
Epic Test ID
1230102136
LOINC
Not available
Beaker LOINC
P1NP: 47255-5
Mayo Access Code
Not available
Reviewed Date
12/13/2021
Beaker Names
Beaker Procedure Name: P1NP, INTACT
Beaker Display Name: P1NP (Procollagen type 1 N-terminal propeptide)
BEAKER TEST NAME: P1NP, Intact
BEAKER TEST REPORT NAME: P1NP (Procollagen type 1 N-terminal propeptide)
Beaker Synonyms
INTACT P1NP
Beaker Collection and Specimen Handling
BEAKER COLLECTION: +S/PO/F
BEAKER SHIPPING & HANDLING: Within 1 hour aliquot serum into a plastic transport tube and freeze immediately.
Beaker Location, Container and Temperature
BW IMMUNOCHEM: GOLD TOP SST TUBE F (Preferred)
BW IMMUNOCHEM: RED TOP F (Acceptable)