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Test Code LAB1230524 P1NP (Procollagen 1 Intact N-Terminal Propeptide)

Test Name Alias

P1NP | PINP | Procollagen peptide | P1NP, Intact

Clinical Information

The amino-terminal propeptide of type 1 procollagen (P1NP) is probably the most specific and sensitive marker for monitoring the efficacy of osteoporosis therapy with anabolic agents, but it is also one of the best bone turnover markers for monitoring the efficacy of antiresorptive therapy.

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Collection Instructions

Specimen Collection: Blood


Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: n/a

Capillary collect ok? Yes

Microtainer acceptable: Yes


Specimen Recommendations

  • Procollagen 1 intact N-terminal (P1NP) values should not be used as a screening test for osteoporosis in the general population.
  • There is diurnal variation of P1NP levels, with the values being higher at night.
  • When serial measurements of P1NP are performed, specimens should be collected at the same time of the day.
  • Fasting versus fed state may also cause variation in results. Therefore fasting sample is recommended.
  • P1NP is metabolized in the liver. In individuals with severe liver disease, clearance from the circulation might be affected resulting in elevated P1NP levels.

Collection Instructions:

  • Fasting sample is recommended.
  • After collection, gently invert gold tube 8 - 10 times to mix clot activator with blood. 
  • Specimen should be processed immediately - see processing instructions

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum


Centrifuge/Spin: Yes

Aliquot: Yes

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge promptly. 
  • Within 1 hour aliquot serum into a plastic transport tube and freeze immediately.

Transport Temperature: Frozen

Rejection Criteria

  • Specimen not centrifuged promptly after collection
  • Serum is not frozen
  • Grossly hemolyzed specimen

Specimen Stability

Ambient: Not acceptable

Refrigerate: Not acceptable

Frozen: Aliquot serum and freeze for longer storage (7 days)

Laboratory Retention: 7 days

Test Frequency

Available Monday, Wednesday and Friday, usual turn-around time 2 - 3 days.

Reference Range

23 mcg/L to 83 mcg/L for male and female

Performing Department


Performing Department Laboratory Location

Spectrum Health Regional Laboratory (SHRL BW), Grand Rapids, MI





CDM Code


Epic Test ID


Interface Order Alias



Not available

Mayo Access Code

Not available

Reviewed Date