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HelpEpic Code LAB172 Valproic Acid, Free and Total, Blood Level
Test Name Alias
Divalproex | Valproate | Dipropylacetic Acid | Divalproex | Valproate | Dipropylacetic Acid | Depakote | Epilim | Valparin | Valpro | Vilapro | Stavzor | 8619
Interface Order Alias
10561
Ordering Instructions
Inpatients: Please contact your local inpatient pharmacy for information regarding appropriate timing for blood drug level orders, if needed.
Collection Instructions
Specimen Collection: Blood
Container(s): 4.5 mL Mint Green Top (Lithium Heparin Gel) or 5.0 mL Gold Top (Serum Separator-SST Gel)
- Preferred Volume to Collect: 4.5 mL
- Minimum Volume to Collect: 2.0 mL
- Neonate Volume to Collect: 1.0 mL
- Capillary collect ok? Yes
- Microtainer acceptable: Yes
Collection Instructions:
- Avoid gross hemolysis
- After collection, gently invert tube 8-10 times.
- Indicate date and time of last dose.
- Specimen should be processed within 2 hours – See Processing Instructions.
Processing Instructions (Laboratory, Outpatient or Off-site collection)
- Processed Specimen: Plasma or Serum
- Centrifuge/Spin: Yes
- Aliquot: Yes
- Processing Instructions:
- Plasma is preferred specimen type
- Green Tube/Plasma: Centrifuge after collection.
- Gold Tube/Serum: Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.
- Transport Temperature: Refrigerate
Specimen Stability
Ambient: 8 hours
Refrigerate: 24 hours (48 hours if aliquoted serum/plasma)
Frozen: aliquot plasma/serum for longer storage
Laboratory Retention: 72 hours
Test Frequency
Available 24 hours, usual TAT 1 day.
Reference Range
% Bound Valproic Acid
87-93 %
% Free Valproic Acid
7-13 %
Free Valproic Acid
5-15 ug/ml
Total Valproic Acid
50-100 ug/ml
Performing Department
Chemistry
Performing Department Laboratory Location
Corewell Health Reference Laboratory, Grand Rapids, MI
Methodology
Homogeneous Enzyme Immunoassay
CPT
80164, 80165
CDM Code
3018016401, 3018016501
Epic Test ID
1230101272
LOINC
Free Valproic Acid: 4087-3
Total Valproic Acid: 4086-5
% Free Valproic Acid: 10548-6
% Bound Valproic Acid: 21590-5
Mayo Access Code
SHO8619
Additional Information
Red top (plain) or Green top (Lithium Heparin, Non-Gel) are also acceptable specimen containers.
Reviewed Date
3/7/2024
Updated Date
3/15/2024 - Reference Range