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Epic Code LAB172 Valproic Acid, Free and Total, Blood Level

Test Name Alias

Divalproex | Valproate | Dipropylacetic Acid | Divalproex | Valproate | Dipropylacetic Acid | Depakote | Epilim | Valparin | Valpro | Vilapro | Stavzor | 8619

Interface Order Alias

10561

Ordering Instructions

Inpatients: Please contact your local inpatient pharmacy for information regarding appropriate timing for blood drug level orders, if needed.

Collection Instructions

Specimen Collection: Blood

 

Container(s): 4.5 mL Mint Green Top (Lithium Heparin Gel) or 5.0 mL Gold Top (Serum Separator-SST Gel)

  • Preferred Volume to Collect: 4.5 mL
  • Minimum Volume to Collect: 2.0 mL
  • Neonate Volume to Collect: 1.0 mL
  • Capillary collect ok? Yes
  • Microtainer acceptable: Yes

 

Collection Instructions:

  • Avoid gross hemolysis
  • After collection, gently invert tube 8-10 times.
  • Indicate date and time of last dose.
  • Specimen should be processed within 2 hours – See Processing Instructions.

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

  • Processed Specimen: Plasma or Serum
  • Centrifuge/Spin: Yes
  • Aliquot: Yes
  • Processing Instructions:
    • Plasma is preferred specimen type
    • Green Tube/Plasma: Centrifuge after collection.
    • Gold Tube/Serum: Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.
    • Minimum volume plasma/serum: 0.5 mL plasma or serum
  • Transport Temperature: Refrigerate

Specimen Stability

Ambient: 8 hours

Refrigerate: 24 hours (48 hours if aliquoted serum/plasma)

Frozen: aliquot plasma/serum for longer storage

Laboratory Retention: 72 hours

Test Frequency

Available 24 hours, usual TAT 1 day.

Reference Range

% Bound Valproic Acid
87-93 %

 

% Free Valproic Acid
7-13 %

 

Free Valproic Acid
5.0-15.0 ug/ml


Total Valproic Acid
50.0-100.0 ug/ml

Laboratoroy Critical Values Table

Performing Department

CHEMISTRY

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI

Methodology

Homogeneous Enzyme Immunoassay

CPT

80164-LAB VALPROIC ACID TOTAL

80165-LAB VALPROIC ACID FREE

CDM Code

4058350, 4059011

Epic Test ID

1230101272

LOINC

Free Valproic Acid: 4087-3

Total Valproic Acid: 4086-5

% Free Valproic Acid: 10548-6

% Bound Valproic Acid: 21590-5

Beaker LOINC

% BOUND VALPROIC ACID: 21590-5
% FREE VALPROIC ACID: 32283-4
FREE VALPROIC ACID: 4087-3
LIPEMIA INDEX, SERUM: N/A
TOTAL VALPROIC ACID: 4086-5

Mayo Access Code

SHO8619

Additional Information

Red top (plain) or Green top (Lithium Heparin, Non-Gel) are also acceptable specimen containers.

Reviewed Date

3/5/2020

Beaker Names

Beaker Procedure Name: VALPROIC ACID TOTAL AND FREE
Beaker Display Name: Valproic Acid, Free and Total
BEAKER TEST NAME: VALPROIC ACID FREE AND TOTAL
BEAKER TEST REPORT NAME: Valproic Acid Free and Total

Beaker Synonyms

No synonym on file

Beaker Location, Container and Temperature

BW CHEMISTRY: GREEN LI HEPARIN PST TUBE R (Preferred)-Refrigerated
BW CHEMISTRY: GOLD TOP SST TUBE R (Acceptable)-Refrigerated