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Epic Code LAB2111376 Chromosome Analysis, Prenatal TEST

Important Note

Please review Ordering Instructions

Test Name Alias

Cytogenetics Prenatal | Karyotype Prenatal | 922

Interface Order Alias

11390

Quick Collect

AP Ambient

Ordering Instructions

Chromosome Analysis, Prenatal is a predictive and presymptomatic genetic test.

 

Submission of an order for any predictive genetic tests and presymptomatic genetic tests, as defined by MCL 333.17020, contained in this catalog constitutes certification to Corewell Health laboratories that the ordering physician understands that written, informed consent is required for these tests and that, by submitting an order for these genetic tests, ordering physician has obtained “Informed Consent” of subject patient as required by any applicable state or federal laws with respect to each test ordered. On occasion, we forward a specimen to an outside reference laboratory. Corewell Health laboratories may request that ordering physician provide such consent to Corewell Health upon a reasonable request.

 

For an example of an informed consent, click here.

Collection Instructions

Multiple specimen collection types. Submit only one:

 

Specimen Collection: Amniotic fluid

Container(s): 2 Sterile screw-capped conical tubes

Preferred volume to collect: 30.0 mL

Minimum volume to collect: 20.0 mL

Collection Instructions:

  • Discard first 2 mL to prevent contamination with maternal cells.
  • 5 – 10 mL will be used for FISH and remaining fluid for chromosome studies.

 

Specimen Collection: Chorionic Villus

Container(s): Sterile transport tube with tissue culture media

Preferred volume to collect: 15 mg

Minimum volume to collect: 15 mg

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Spin: No

Aliquot: No

 

Transport Temperature: Ambient

If ambient temperature exceeds 80°F or is below 40°F, please send in an insulated container. All samples should be directed to the laboratory as soon as possible.

Specimen Stability

Ambient: 3 days (beyond 3 days, specimen viability will be determined by Cytogenetics Lab.

Laboratory Retention: Cultured amniocytes or mesenchymal cells are maintained until 2 weeks following final report.

Test Frequency

Test Set Up: Monday – Friday 8:00 am – 5:00 pm, Saturday 8:00 am – 3:00 pm.

Technologist on call for Sunday set up.

Final report: 7 – 14 days.

Reference Range

An interpretative report will be provided.

Performing Department

Cytogenetics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI

Methodology

Amniocytes (from Amniotic Fluid) or mesenchymal cells (from Chorionic villus core) are cultured for 6 to 10 days and arrested at metaphase with Colcemid. Chromosomes are stained by the G-banding method. The chromosome number is determined by microscopic analysis and cells are examined for presence or absence of detectable structural rearrangements. The test includes 2 banded fetal karotypes, analysis of metaphases of 20 cells or 14-15 colonies from 2 or more primary cultures.

CPT

88235, 88269, 88280

Epic Test ID

1230100595

Reviewed Date

4/28/2023