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Epic Code LAB2111418 Her-2/neu (ERBB2) Amplification by FISH

Test Name Alias

Her-2/neu (ERBB2) by FISH | ERBB2 Amplification | 956

Interface Order Alias

11432

Quick Collect

AP Ambient

Clinical Information

Fluorescence in situ hybridization (FISH) using HER-2/neu (ERBB2) DNA probe is useful in the identification of normal and amplified genomic sequences in tumor tissue (e.g. breast or gastric cancer).

Collection Instructions

Multiple specimen collection types. Submit only one.

 

Specimen Collection: Formalin-fixed, paraffin-embedded (FFPE) tissue

Container(s): Block

Preferred Volume to Collect: 4 unstained slides cut between 4 and 6 microns thick

Collection Instructions:

  • Include an H&E slide scribed by Pathologist and Surgical Specimen Testing order sheet.
  • Place specimen in 10% Formalin and order Tissue Pathology in addition to Her-2/neu (ERBB2) Amplification by FISH order.

  • Provide a pathology report with each tissue specimen. The report must include type/length of fixation (i.e. fixed in 10% neutral buffered formalin >6 and <72 hours)

 

Specimen Collection: Fine Needle Aspirate (FNA, such as lymph node)

Collection Instructions: Order FNA Cytology (refer to test code 202 for collection instructions) in addition to Her-2/neu (ERBB2) Amplification by FISH order. Provide a pathology report with each tissue specimen. The report must include type/length of fixation (i.e. fixed in 10% neutral buffered formalin >6 and <72 hours)

 

 

Specimen Collection:  Pleural Fluid

Collection instructions:  Place specimen in sterile container and order Medical Cytology in addition to Her-2/neu (ERBB2) Amplification by FISH order. Provide a pathology report with each tissue specimen. The report must include type/length of fixation (i.e. fixed in 10% neutral buffered formalin >6 and <72 hours)

Processing Instructions (Laboratory, Outpatient or Off-site collection)

 

Spin: No

Aliquot: No

 

Transport Temperature: Ambient

If ambient temperature exceeds 80°F or is below 40°F, please send in an insulated container. All samples should be directed to the laboratory as soon as possible.

Reflex Information

Reflex approved by MEC

Test Frequency

Test Set Up: Monday – Friday 8:00 am – 5:00 pm, Saturday 8:00 am – 3:00 pm.

Technologist on call for Sunday set up.

Final report: 2-7 days.

Reference Range

An interpretative report will be provided.

Performing Department

Cytogenetics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI

Methodology

Performed by fluorescence in situ hybridization (FISH). This test was developed and its performance characteristics determined by Spectrum Health Cytogenetics Laboratory. It has not been cleared or approved by the US FDA. The FDA has determined that such clearance is not necessary. This test is used for clinical purposes.

CPT

88368, 88369

CDM Code

3108836801, 3108836901

Epic Test ID

1230100769

LOINC

Specimen Type: 66746-9

Indication Provided: 42349-1

Result: in process

Interpretation: 59050-5

Comments: 69965-2

Reviewed Date

4/28/2023