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Epic Code LAB313 D-Dimer

Important Note

There is currently a nationwide shortage of this tube. Please take steps to ensure specimen integrity to reduce recollection. Specimen Tube Shortage (link)

Test Name Alias

D-Dimer r/o Pulmonary Embolism | D-Dimer vidas | D-Dimervidas | 8605

Interface Order Alias


Quick Collect


Clinical Information

Test is used to evaluate Pulmonary Embolism (PE), Deep Vein Thrombosis (DVT), and DIC.


It should be noted that the published studies evaluating this assay have included only Emergency Room or other outpatient presenting with new symptoms suggestive of thromboembolic disease. This assay has not been evaluated for this purpose in hospital inpatients, postoperative patients, or other patient types than those indicated.


Elevated D-Dimers may be seen in activation states of coagulation.  Elevated states of D-Dimer levels may be associated with the following:  DVT, DIC, hemorrhages, fibrinolysis, post-operative periods, cancer, and severe infections.  D-Dimer levels may be falsely elevated in underlying, non-thrombotic conditions common in hospitalized patients.  Cut-off value for D-dimer use in evaluation of VTE is 500 ng/mL FEU.


The measurement of D-Dimer should not be used as an aid in the diagnosis of VTE in patients with:

  • Therapeutic dose anticoagulant therapy for >24 hours
  • Fibrinolytic therapy within previous 7 days
  • Trauma or surgery within previous 4 weeks
  • Aortic aneurysm
  • Sepsis, severe infections, pneumonia, severe skin infections
  • Liver cirrhosis
  • Renal Failure
  • Pregnancy

The American College of Emergency Physicians, the American College of Physicians and the American Society of Hematology recommend that in patients older than 50 years with low-to-intermediate pretest probability for acute pulmonary embolism, an age-adjusted D-dimer cutoff of age x 10 (FEU units) can be used to exclude a diagnosis of PE without need for further imaging.

Ann Emerg Med. 2018;71:e59-e109 Ann Intern
Med.2015;163:701-711 Blood Adv 2018;2:3226

Collection Instructions

Specimen Collection: Blood


Container(s): 3.2% Na. Citrate (blue top)

Preferred Volume to Collect: 2.7 mL (full tube)

Minimum Volume to Collect: 1.8 mL (full tube)

Capillary collect ok: No

Microtainer acceptable: No


Collection Instructions:

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Platelet Poor Plasma


Centrifuge/Spin: Yes

Aliquot: Yes


Processing Instructions:

  • Detailed Instructions (link): Preparing Platelet Poor Plasma
  • Separate plasma into 1-2 aliquots, minimum of 0.5 mL each.
  • Freeze aliquots in plastic transport tubes immediately.

Transport Temperature:

  • Ambient (up to 4 hours in whole blood state)
  • Frozen (plasma only >4 hours)

Rejection Criteria

  • Hemolysis
  • Specimen has been thawed

Specimen Stability

Ambient: 4 hours

Frozen: Aliquot plasma for longer storage

Laboratory Retention: 24 hours

Test Frequency

Available 24 hours, usual TAT 1 hour.

Reference Range

0 – 500 ng/mL FEU

Performing Department


Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI
Corewell Health Big Rapids Laboratory, Big Rapids, MI
Corewell Health Blodgett Laboratory, Grand Rapids, MI
Corewell Health Gerber Laboratory, Fremont, MI
Corewell Health Kelsey Laboratory, Lakeview, MI
Corewell Health Ludington Laboratory, Ludington, MI
Corewell Health Pennock Laboratory, Hastings, MI
Corewell Health Reed City Laboratory, Reed City, MI
Corewell Health Greenville Laboratory, Greenville, MI
Corewell Health Zeeland Laboratory, Zeeland, MI


Immunoassay turbidmetric



CDM Code


Epic Test ID



D-Dimer Quant: 48065-7

Reviewed Date