Epic Code LAB313 D-Dimer
Test Name Alias
D-Dimer r/o Pulmonary Embolism | D-Dimer vidas | D-Dimervidas | 8605
Interface Order Alias
10123
Clinical Information
Test is used to evaluate Pulmonary Embolism (PE), Deep Vein Thrombosis (DVT), and DIC.
It should be noted that the published studies evaluating this assay have included only Emergency Room or other outpatient presenting with new symptoms suggestive of thromboembolic disease. This assay has not been evaluated for this purpose in hospital inpatients, postoperative patients, or other patient types than those indicated.
Elevated D-Dimers may be seen in activation states of coagulation. Elevated states of D-Dimer levels may be associated with the following: DVT, DIC, hemorrhages, fibrinolysis, post-operative periods, cancer, and severe infections. D-Dimer levels may be falsely elevated in underlying, non-thrombotic conditions common in hospitalized patients. Cut-off value for D-dimer use in evaluation of VTE is 500 ng/mL FEU.
The measurement of D-Dimer should not be used as an aid in the diagnosis of VTE in patients with:
- Therapeutic dose anticoagulant therapy for >24 hours
- Fibrinolytic therapy within previous 7 days
- Trauma or surgery within previous 4 weeks
- Aortic aneurysm
- Sepsis, severe infections, pneumonia, severe skin infections
- Liver cirrhosis
- Renal Failure
- Pregnancy
The American College of Emergency Physicians, the American College of Physicians and the American Society of Hematology recommend that in patients older than 50 years with low-to-intermediate pretest probability for acute pulmonary embolism, an age-adjusted D-dimer cutoff of age x 10 (FEU units) can be used to exclude a diagnosis of PE without need for further imaging.
Ann Emerg Med. 2018;71:e59-e109 Ann Intern
Med.2015;163:701-711 Blood Adv 2018;2:3226
Icons & Photos
Collection Instructions
Specimen Collection: Blood
Container(s): 3.2% Na. Citrate (blue top)
Preferred Volume to Collect: 2.7 mL (full tube)
Minimum Volume to Collect: 1.8 mL (full tube)
Capillary collect ok: No
Microtainer acceptable: No
Collection Instructions:
-
Detailed instructions (link): Anticoagulant Correction for High Hematocrit
-
Detailed instructions (link): Blue Citrate Tube
- Specimen should be processed within 4 hours – See Processing Instructions below.
Processing Instructions (Laboratory, Outpatient or Off-site collection)
Processed Specimen: Platelet Poor Plasma
Centrifuge/Spin: Yes
Aliquot: Yes
Processing Instructions:
- Detailed Instructions (link): Preparing Platelet Poor Plasma
- Separate plasma into 1-2 aliquots, minimum of 0.5 mL each.
- Freeze aliquots in plastic transport tubes immediately.
Transport Temperature:
- Ambient (up to 4 hours in whole blood state)
- Frozen (plasma only >4 hours)
Rejection Criteria
- Hemolysis
- Specimen has been thawed
Specimen Stability
Ambient: 4 hours
Frozen: Aliquot plasma for longer storage
Laboratory Retention: 24 hours
Test Frequency
Available 24 hours, usual TAT 1 hour.
Reference Range
0 – 500 ng/mL FEU
Performing Department
COAGULATION
Performing Department Laboratory Location
Spectrum Health Regional Laboratory, Grand Rapids, MI
Spectrum Health Big Rapids Laboratory, Big Rapids, MI
Spectrum Health Blodgett Laboratory, Grand Rapids, MI
Spectrum Health Gerber Laboratory, Fremont, MI
Spectrum Health Kelsey Laboratory, Lakeview, MI
Spectrum Health Ludington Laboratory, Ludington, MI
Spectrum Health Pennock Laboratory, Hastings, MI
Spectrum Health Reed City Laboratory, Reed City, MI
Spectrum Health United Laboratory, Greenville, MI
Spectrum Health Zeeland Laboratory, Zeeland, MI
Methodology
Immunoassay turbidmetric
CPT
85379
CDM Code
80101933
Epic Test ID
1230100600
LOINC
D-Dimer Quant: 48065-7
Beaker LOINC
DDIMER QUANT MDI RESULT: N/A
D-DIMER QUANT: 48065-7
Reviewed Date
10/11/2021
Beaker Names
Beaker Procedure Name: D-DIMER,QUANTITATIVE
Beaker Display Name: D-Dimer
BEAKER TEST NAME: D-DIMER QUANT FOR PE/DVT
BEAKER TEST REPORT NAME: D-Dimer Quant for PE/DVT
Beaker Synonyms
No synonym on file
Beaker Collection and Specimen Handling
BEAKER COLLECTION: +(4)S10/POx1/F
Beaker Location, Container and Temperature
BW COAGULATION: BLUE TOP TUBE (Preferred)
BL COAGULATION: BLUE TOP TUBE (Preferred)
BR COAGULATION: BLUE TOP TUBE (Preferred)
GM COAGULATION: BLUE TOP TUBE (Preferred)
KL COAGULATION: BLUE TOP TUBE (Preferred)
LH COAGULATION: BLUE TOP TUBE (Preferred)
PH COAGULATION: BLUE TOP TUBE (Preferred)
RC COAGULATION: BLUE TOP TUBE (Preferred)
UN COAGULATION: BLUE TOP TUBE (Preferred)
ZH COAGULATION: BLUE TOP TUBE (Preferred)