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Epic Code LAB3322 Celiac Antibody Cascade

Test Name Alias

Celiac Disease Reflexive Cascade | Celiac Serology | Celiac Panel | 7016

Interface Order Alias

11632

Clinical Information

CASCADE INFORMATION

 

Transglutaminase Ab IgA and total IgA are initially performed. Further testing may be automatically ordered based on reflexing algorithm. 

  • If total IgA is normal or high and tTG IgA is weakly positive (15-30):  Endomysial Antibody IgA will reflex. 
  • If total IgA is low and tTG IgA is <15 or >30: Transglutaminase IgG, Gliadin IgA, and Gliadin IgG will reflex.
  • If total IgA is low and tTG IgA is weakly positive (15-30): Transglutaminase IgG, Gliadin IgA, Gliadin IgG, and Endomysial IgA will reflex.
     

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok: Yes

Microtainer acceptable: Yes

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed within 2 hours – See Processing Instructions.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

  • Processed Specimen: Serum
  • Centrifuge/Spin: Yes
  • Aliquot: No
  • Processing Instructions:
    • Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.
    • Minimum volume: 1.0 mL Serum
  • Transport Temperature: Refrigerated

Rejection Criteria

Specimen not centrifuged within 2 hours

Specimen Stability

Ambient: 8 hours

Refrigerate: 7 days

Frozen: Aliquot serum for longer storage (-20°C)

Laboratory Retention: 7 days

Reflex Information

Link: Mandatory Reflex approved by MEC

Test Frequency

Available Monday through Friday, usual TAT 1 to 3 days.

Reference Range

Transglutaminase Ab IgA Reference Range: <15 U/mL

IgA

Age mg/dl
0 up to 1 month 0 - 10
1 month up to  1 year 10 - 100
1 year up to 4 years 20 - 150
4 years up to 10 years 40 - 200
10 years up to 13 years 50 - 250
13 years up to Unspecified 60 - 350


 

Performing Department

Multiple Departments: Chemistry and Immunochemistry

Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI

Methodology

Transglutaminase Ab IgA: Multiplex Flow Immunoassay

Total IgA: Roche Cobas

CPT

83516, 82784
Additional charges may apply based on reflexes

CDM Code

3018351619, 3018278403

Epic Test ID

1230100464

Mayo Access Code

SHO11632

Reviewed Date

3/23/2022

Updated Date

1/26/2024 - Clinical Information, Reference Range, and Methodology