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HelpEpic Code LAB3411 Autoimmune Lymphoproliferative Syndrome (ALPS) Screen by Flow Cytometry
Test Name Alias
ALPS Screen by Flow Cytometry | Autoimmune Lymphoproliferative Syndrome | Double Negative T Cells | DNT | 708
Interface Order Alias
30512
Quick Collect
AP Ambient
Clinical Information
The ALPS Screen by Flow Cytometry is a sensitive screening test for Autoimmune Lymphoproliferative Syndrome. Peripheral whole blood is stained with fluorescent labeled CD3, TCRαβ+, CD4, and CD8 monoclonal antibodies and the TCRαβ+ DNT cells in the blood are quantitated. Patients with ALPS, a rare disorder of dysregulated lymphocyte homeostasis, have an increased percentage of CD3+/TCRαβ+ cells which lack CD4 and CD8 (double negative T cells).
Specimen Requirements
Specimen Type: Whole Blood EDTA
Container/Tube: Lavender Top (EDTA)
Volume: 3mL
Pediatric Volume: 0.5 mL
Minimum volume: 1 mL
Collection Instructions: Transport as soon as possible
Specimen Transport Temperature
Ambient
Rejection Criteria
Specimens that do not meet Spectrum Health Laboratory standards may be rejected (cancelled) due to:
- Refrigerated specimen
- Clotted
- Grossly hemolyzed
Specimen Stability
Ambient: 48 hours
Note: Specimen must remain ambient as all times and testing must be performed within 48 hours of collection
Test Frequency
Available Monday – Friday, usual TAT 2 days
Reference Range
See report: See patient chart report for interpretation
Performing Department
Flow Cytometry
Performing Department Laboratory Location
Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI
Methodology
Flow Cytometry
CPT
88184, 88185 x3
First cell surface marker will be billed with CPT code 88184. Each additional surface marker will be billed with CPT code 88185. The quantity of surface markers varies with each patient case and will be billed accordingly based on quantity performed. Corresponding professional fees may also apply.
CDM Code
3108818504, 3108818404
Epic Test ID
1230100367
LOINC
In process
Reviewed Date
4/28/2023