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Test Code LAB3424 IgE Peanuts, Component Allergen Panel

Important Note

Component allergen panel is only to be ordered as an “add on” follow-up to orders on patients with previous positive results for the allergen involved.

Test Name Alias

allergen | ImmunoCAP|RAST| Allergy | Allergen panel | Allergen Profile | Component Allergen | 7006

Clinical Information

IgE antibodies to Ara h 1, Ara h 2, Ara h 3, and Ara h 6 components are associated with higher risk of anaphylactic and other systemic reactions to peanut exposure. Antibodies to Ara h 2 are nearly always associated with clinical peanut allergy. Patients with IgE antibodies to any of these components need to strictly avoid all exposure to peanut products.

Antibodies to Ara h 9 component are associated with variable risk of anaphylactic and other systemic reactions to peanut exposure. These antibodies may be cross reactive to peach and other fruits with pits. Patients with IgE antibodies to Ara h 9 (with or without antibodies to Ara h 8) but no antibodies to Ara h 1, Ara h 2, Ara h 3, or Ara h 6 may or may not need to avoid peanut exposure, depending on clinical history of symptoms.

Antibodies to Ara h 8 component are associated with lower risk of systemic reactions. These antibodies may be cross reactive with birch and other pollens. Oral food challenge may be indicated for patients with IgE antibodies to Ara h 8 only. If oral food challenge is negative, avoidance of peanut consumption or exposure may not be necessary.

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: Full tube (5 mL)

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok? Yes

Microtainer acceptable: Yes

Collection Instructions:

  • Gently invert gold tube(s) 8 – 10 times to mix clot activator with blood.
  • Specimen should be processed within 2 hours – See Processing Instructions.
  • 1 full tube per 15 – 20 allergens.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: No

Processing Instructions: Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.

Transport Temperature: Refrigerate

Rejection Criteria

  • Quantity not sufficient (QNS)
  • Specimen not centrifuged within 2 hours

Specimen Stability

Ambient: 12 hours
Refrigerate: 7 days
Frozen: aliquot serum for longer storage
Laboratory Retention: 30 days

Reflex Information

If Peanut IgE IgE is greater than or equal to 0.10 kU/L, then Peanut Component IgE Panel (Peanut Ara h 1 IgE, Peanut Ara h 2 IgE, Peanut Ara h 3 IgE, Peanut Ara h 6 IgE, Peanut Ara h 8 IgE, Peanut Ara h 9 IgE) will be ordered.

Test Frequency

Available Monday through Friday, usual TAT 1-3 days.

Reference Range

<0.10 kU/L

Performing Department

IMMUNOCHEMISTRY

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI

Methodology

ImmunoCAP® System Fluorescence Enzyme Immunoassay (FEIA)

CPT

86008 x6

CDM Code

4026787

Epic Test ID

1230100197

Interface Order Alias

11721

Interface Information

Not available

Mayo Access Code

SHO11721

Additional Information

Lab Staff:
For 1 allergen: 0.3mL serum
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25mL dead space
1 tube per panel

Reviewed Date

12/30/2019