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Epic Code LAB346 Factor V Leiden DNA Analysis

Important Note

Please review Ordering Instructions

Test Name Alias

Factor V LeidenDNA Analysis | HypercoagulationDNA Analysis | 77 | Factor 5 | FVL

Interface Order Alias

10509

Quick Collect

+A

Clinical Information

Factor V Leiden DNA analysis detects a point mutation of Factor V gene R506Q, and is suggested for patients with inherited thrombophilia.

Patients on heparin therapy and blood transfusion patients may have blood specimens that potentially interfere leading to invalid or erroneous results.

Ordering Instructions

Factor V Leiden DNA Analysis is a predictive and presymptomatic genetic test.

Submission of an order for any predictive genetic tests and presymptomatic genetic tests, as defined by MCL 333.17020, contained in this catalog constitutes certification to Corewell Health laboratories that the ordering physician understands that written, informed consent is required for these tests and that, by submitting an order for these genetic tests, ordering physician has obtained “Informed Consent” of subject patient as required by any applicable state or federal laws with respect to each test ordered. On occasion, we forward a specimen to an outside reference laboratory. Corewell Health laboratories may request that ordering physician provide such consent to Corewell Health upon a reasonable request.

For an example of an informed consent, click here.

Collection Instructions

Specimen Collection: Blood

 

Container(s): Lavender Top (EDTA) 3.0 mL

Preferred Volume to Collect: 3.0 mL

Minimum Volume to Collect: 1.0 mL

Neonate Volume to Collect: 1.0 mL

 

Collection Instructions:

  • Gently invert 8 - 10 times after collection.
  • For optimal results, specimen should be received within 24 hours of collection. Send specimen same day of collection.

  • If one or more of the following tests are ordered simultaneously, only one EDTA tube needs to be collected:

    • Factor V Leiden DNA Analysis
    • Prothrombin G20210A

 

Processing Instructions (Laboratory, Outpatient or Off-site collection)

  • Processed Specimen: Whole Blood EDTA
  • Centrifuge/Spin: No
  • Aliquot: No
  • Transport Temperature: Ambient

 

Specimen Stability

Ambient: 24 hours

Refrigerated: 15 days

Laboratory Retention: 3 months

Test Frequency

Available at least twice per week; usual TAT 3-5 days 

Reference Range

Negative

Performing Department

Molecular Diagnostics

Performing Department Laboratory Location

Corewell Health Advanced Technology Laboratory (ATL), Grand Rapids, MI

Methodology

Multiplex Polymerase Chain Reaction (PCR) followed by detection using scorpion probes
 

CPT

81241

CDM Code

3108124101

Epic Test ID

1230100669

LOINC

Factor V Leiden DNA: 21668-9

Factor V Leiden, Interp: 8251-1

Mayo Access Code

SHO077

Reviewed Date

6/22/2023

Last Updated Date

9/22/2022