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Epic Code LAB3535 Somatomedin C Blood Level (Insulin Like Growth Factor 1, IGF-1)

Test Name Alias

8055

Interface Order Alias

11789

Quick Collect

+(1)S/PO/F

Clinical Information

Useful For

  • Diagnosing growth disorders
  • Diagnosing adult growth hormone deficiency
  • Monitoring of recombinant human growth hormone treatment
  • Diagnosis and follow-up of acromegaly and gigantism

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 1.0 mL

Capillary collect ok: Yes

Microtainer acceptable: Yes

Collection Instructions:

  • Gently invert gold tube(s) 8-10 times to mix clot activator with blood.
  • Specimen should be processed immediately – See Processing Instructions

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: Yes

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge promptly.
  • Within an hour aliquot serum into a plastic transport tube and freeze as soon as possible.
  • (+(1)S/PO/F)

Transport Temperature: Frozen

Rejection Criteria

  • Specimen not centrifuged promptly after collection.

  • Centrifuged serum not meeting specimen stability requirements.

Specimen Stability

Serum

  • Ambient:  8 hours
  • Refrigerated:  24 hours
  • Frozen:  28 days
  • Laboratory Retention:  7 days

Test Frequency

Available Monday, Wednesday and Friday, usual TAT 1 to 3 days

Reference Range

Males:

 

Age

ng/mL

0-11 months

15-150

1 year

18-179

2 years

22-204

3 years

25-224

4 years

28-241

5 years

32-259

6 years

36-281

7 years

42-311

8 years

49-351

9 years

58-401

10 years

70-458

11 years

82-516

12 years

93-567

13 years

103-603

14 years

111-620

15 years

115-618

16 years

115-598

17 years

113-566

18 years

109-527

19 years

104-484

20 years

98-443

21-25 years

83-344

26-30 years

75-275

31-35 years

71-241

36-40 years

69-226

41-45 years

64-210

46-50 years

59-201

51-55 years

56-201

56-60 years

51-194

61-65 years

47-191

66-70 years

46-195

71-75 years

42-187

76-80 years

39-184

80-85 years

37-182

85-90 years

35-182

 

Females:

 

Age

ng/mL

0-11 months

18-146

1 year

20-159

2 years

23-177

3 years

27-198

4 years

32-223

5 years

36-246

6 years

41-269

7 years

48-299

8 years

56-339

9 years

68-396

10 years

83-465

11 years

99-537

12 years

115-598

13 years

126-637

14 years

133-647

15 years

134-631

16 years

130-595

17 years

123-546

18 years

114-493

19 years

105-441

20 years

97-398

21-25 years

84-323

26-30 years

77-271

31-35 years

73-244

36-40 years

68-225

41-45 years

62-205

46-50 years

56-194

51-55 years

53-191

56-60 years

45-173

61-65 years

41-168

66-70 years

39-168

71-75 years

36-166

76-80 years

35-168

80-85 years

35-179

85-90 years

33-179

Reference values have not been established for patients that are> 90 years of age.

 

IGF-1 reference values according to Tanner stages I-V

Males

Stage I: 83-255 ng/mL

Stage II: 114-440 ng/mL

Stage III: 236-516 ng/mL

Stage IV: 218-580 ng/mL

Stage V: 229-522 ng/mL

Females

Stage I: 90-324 ng/mL

Stage II: 104-456 ng/mL

Stage III: 249-519 ng/mL

Stage IV: 238-574 ng/mL

Stage V: 187-509 ng/mL

 

Note: Puberty onset, ie the transition from Tanner stage 1 (prepubertal) to Tanner stage 2 (early pubertal), occurs for girls at a median age of 10.5 (±2) years and for boys at a median age of 11.5 (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African-American girls. By contrast, for boys there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage 5 (young adult) should be reached by age 18.

Performing Department

Immunochemistry

Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI

Methodology

Chemiluminescence

CPT

84305

CDM Code

3018430501

Epic Test ID

1230101180

LOINC

IGF-1: 2484-4

Mayo Access Code

SHO11789

Reviewed Date

12/13/2022