Clinical Information

IgE antibodies to rAna o 3 (Cashew Nut Storage Protein) are associated with systemic reactions to cashews. Sensitization to this component allergen is also associated with a higher risk of sensitization to pistachios.

Component testing for Cashew Nut must be ordered as follow-up to whole allergen results.This test is not available as a reflex test. Patient specimens are stored frozen for 30 days.

Component testing measures IgE antibodies to individual proteins unlike whole allergen testing which measures the presence of specific immunoglobulin E (sIgE) antibodies to a combination of allergenic and non-allergenic proteins.This next generation testing identifies the source of sensitization and helps the clinician assess the risk of systemic reaction.

Results of component testing can assist with patient selection for oral food challenge as well as possible management recommendations such as immunotherapy and/or allergen avoidance/food elimination. Because of the diagnostic and management complexities associated with food allergy, referral to an allergy and immunology specialist should be considered when evaluating a patient with suspected food allergies.