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Epic Code LAB477 Levetiracetam Level

Test Name Alias

Keppra | 3140

Interface Order Alias

10822

Collection Instructions

Specimen Collection: Blood

 

Container(s): Red top (no additive)

Preferred Volume to Collect: 3.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok? Yes

Microtainer acceptable?  Yes

 

Collection Instructions:

  • After collection, gently invert tube 8-10 times.
  • Specimen should be processed – See Processing Instructions.

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: Yes

 

Processing Instructions:

  • When tubes are clotted (30-45 minutes), centrifuge specimens
  • Pipette serum into aliquot tube

Minimum serum volume: 1.0 mL

 

Transport Temperature: Ambient

Specimen Stability

Ambient: 72 hours

Refrigerate: 7 days

Frozen: 14 days

Laboratory Retention: 7 days

Test Frequency

Available 24 hours, usual TAT 1 day.

STAT TAT 2 hours

 

Reference Range

  1.  
  • Normal range is 6 to 46 µg/mL
  • Normal range is derived from trough samples

 

Brivaracetam (Briviact®) interferes with measurements of levetiracetam (Keppra®) in the ARK Levetiracetam Assay. Patients undergoing a switch in drug therapy involving Keppra and Briviact should not be monitored for levetiracetam using the ARK assay. Serum levels of levetiracetam and/or brivaracetam should be confirmed by a valid chromatographic method if there is a possibility these drugs are co-present in circulation.

Performing Department

Toxicology

Performing Department Laboratory Location

Corewell Health Reference Laboratory, Grand Rapids, MI

Methodology

Colorimetric

CPT

80177

CDM Code

3018017701

Epic Test ID

1230100884

LOINC

Levetiracetam Lvl: 30471-7

Mayo Access Code

SHO3140

Reviewed Date

2/15/2023