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Epic Code LAB489 Protein C Activity

Important Note

There is currently a nationwide shortage of this tube. Please take steps to ensure specimen integrity to reduce recollection. Specimen Tube Shortage (link)

Test Name Alias

Protein C Activity | 8381

Interface Order Alias

10230

Clinical Information

Protein C is a vitamin K dependent plasma protein which plays an important role in the anticoagulant regulatory mechanisms, specifically as it relates to thrombin generation. Activated protein C with its cofactor, protein S, regulates the coagulation system by proteolytic cleavage and inactivation of activated factors Va and VIIIa.

 

Intended Use: The functional protein C activity assay is used for the evaluation of patients suspected of having inherited or acquired protein C deficiency. May be used for the evaluation of a thrombophilia risk evaluation in patients with a personal or family history of a thrombotic event.

Icons & Photos

Collection Instructions

Container(s): 3.2% Na Citrate Tube (blue top)

Preferred Volume to Collect: 2.7 mL (full tube)

Minimum Volume to Collect: 1.8 mL (full tube)

Capillary collect ok: No

Microtainer acceptable: No

 

Collection Instructions:

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Platelet Poor Plasma

 

Centrifuge/Spin: Yes

Aliquot: Yes

 

Processing Instructions:

  • Detailed instructions (link): Preparing Platelet Poor Plasma
  • Separate plasma into 2 – 3 aliquots, minimum of 0.5 mL each.
  • Freeze aliquots in plastic transport tubes immediately.

Transport Temperature:

  • Ambient (up to 1 hour in whole blood state)
  • Frozen (plasma only >1 hours)

Rejection Criteria

  • Hemolysis
  • Specimen has been thawed

Specimen Stability

Ambient: 1 hour

Frozen: 2 months

Laboratory Retention: 2 months

Test Frequency

Monday-Friday, usual TAT is 1-4 days.

Reference Range

Adult: 75 – 150 %

Pediatric reference ranges have not been established

Performing Department

COAGULATION

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI

Methodology

Chromogenic Assay

CPT

85303

CDM Code

4028381

Epic Test ID

1230101081

LOINC

Protein C Activity: 27818-4

Beaker LOINC

PROTEIN C ACTIVITY: 27818-4

Mayo Access Code

SHO105

Reviewed Date

10/11/2021

Beaker Names

Beaker Procedure Name: PROTEIN C ACTIVITY
Beaker Display Name: Protein C Activity
BEAKER TEST NAME: PROTEIN C ACTIVITY
BEAKER TEST REPORT NAME: Protein C Activity

Beaker Synonyms

No synonym on file

Beaker Collection and Specimen Handling

BEAKER COLLECTION: +(1)S10/POx3/F

Beaker Location, Container and Temperature

BW COAGULATION: BLUE TOP TUBE