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Epic Code LAB736 Cadmium, Blood

Additional Codes

Mayo Code: CDB

Epic code: LAB 736

Interface Order Alias: 11582

Cerner: 2011

 

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detecting exposure to cadmium, a toxic heavy metal

Specimen Type

Whole blood


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube

Specimen Volume: Full tube

Collection Instructions:

1. See Metals Analysis Specimen Collection and Transport for complete instructions.

2. Send whole blood specimen in original collection tube. Do not aliquot.


Laboratory Test Directory Note:

Which royal blue tube should I use?

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Day(s) Performed

Monday through Saturday

Reference Values

<5.0 ng/mL

Reference values apply to all ages.

Clinical Information

The toxicity of cadmium resembles the other heavy metals (arsenic, mercury, and lead) in that it attacks the kidney; kidney dysfunction with proteinuria with slow onset (over a period of years) is the typical presentation.

 

Breathing the fumes of cadmium vapors leads to nasal epithelial deterioration and pulmonary congestion resembling chronic emphysema.

 

The most common source of chronic exposure comes from spray painting organic-based paints without a protective breathing apparatus; auto repair mechanics represent a susceptible group for cadmium toxicity. In addition, another common source of cadmium exposure is tobacco smoke.

Cautions

No significant cautionary statements

Interpretation

Normal blood cadmium is less than 5.0 ng/mL, with most results in the range of 0.5 to 2.0 ng/mL.

 

Acute toxicity will be observed when the blood level exceeds 50 ng/mL.

Reporting Name

Cadmium, B

Method Name

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Method Description

The metal of interest is analyzed by inductively coupled plasma mass spectrometry.(Unpublished Mayo method)

CPT Code Information

82300

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CDB Cadmium, B 5609-3

 

Result ID Test Result Name Result LOINC Value
8682 Cadmium, B 5609-3

Report Available

1 to 2 days

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Clinical Reference

1. Moreau T, Orssaud G, Lellouch J, Claude JR, Juguet B, Festy B: Blood cadmium levels in a general population with special reference to smoking. Arch Environ Health. 1983;38(3):163-167

2. Strathmann FG, Blum LM: Toxic elements. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 44

Laboratory Test Catalog Additional Information:

Quick Guide: Which Royal Blue Tube Should I Use?