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HelpEpic Code LAB736 Cadmium, Blood
Additional Codes
Mayo Code: CDB
Epic code: LAB 736
Interface Order Alias: 11582
Cerner: 2011
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Detecting exposure to cadmium, a toxic heavy metal
Specimen Type
Whole bloodSpecimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube
Specimen Volume: Full tube
Collection Instructions: Send specimen in original tube.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole blood | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Cautions
No significant cautionary statements
Clinical Information
The toxicity of cadmium resembles the other heavy metals (arsenic, mercury, and lead) in that it attacks the kidney; renal dysfunction with proteinuria with slow onset (over a period of years) is the typical presentation.
Breathing the fumes of cadmium vapors leads to nasal epithelial deterioration and pulmonary congestion resembling chronic emphysema.
The most common source of chronic exposure comes from spray painting of organic-based paints without use of a protective breathing apparatus; auto repair mechanics represent a susceptible group for cadmium toxicity. In addition, another common source of cadmium exposure is tobacco smoke.
Method Name
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
Report Available
1 to 2 daysReporting Name
Cadmium, BReference Values
<5.0 ng/mL
Reference values apply to all ages.
Interpretation
Normal blood cadmium is <5.0 ng/mL, with most results in the range of 0.5 to 2.0 ng/mL.
Acute toxicity will be observed when the blood level exceeds 50 ng/mL.
Method Description
Cadmium (Cd)is analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) in kinetic energy discrimination (KED) mode using helium as a non-reactive gas to collide with polyatomic interferences such as argon chloride (ArCl). Internal standard used is rhodium (Rh). A salt matrix calibration is used.(Unpublished Mayo method)
Day(s) Performed
Monday through Saturday
Clinical Reference
1. Moreau T, Lellouch J, Juguet B, et al: Blood cadmium levels in a general population with special reference to smoking. Arch Environ Health. 1983;38:163-167
2. Strathmann FG, Blum LM: Toxic Elements. In: Rafai N, Horwath AR., Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 6th ed. Elsevier, 2018;chap 42
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82300
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CDB | Cadmium, B | 5609-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8682 | Cadmium, B | 5609-3 |
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