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Epic Code LAB7610 Fibrin Degradation Products (FDP)

Important Note

There is currently a nationwide shortage of this tube. Please take steps to ensure specimen integrity to reduce recollection. Specimen Tube Shortage (link)

Test Name Alias

Fibrin Degradation Products | FDP | 8415

Interface Order Alias

10039

Clinical Information

Useful for the detection and semi-quantitation of fibrin/fibrinogen degradation products in plasma with latex particles which are coated with monoclonal antibodies to FDP. 

 

Abnormal fibrinolytic and or fibrinogenolytic activity demonstrated by elevated levels of FDP in plasma may be seen in the following:

  • DIC
  • Eclampsia
  • Carcinoma
  • Post-operative
  • Cardiac or hepatic disorders
  • Fibrinolysis
  • Pulmonary embolism
  • Deep vein thrombosis

 

Interpretation:

Free D and E domains as well as X and Y fragments detected by this method may be produced by degradation of either fibrin clot or circulating fibrinogen.

In cases where the FDP assay is positive and it is desired to distinguish lysis of fibrin from intravascular fibrinolysis, it is recommended to suggest the D-Dimer assay.

 

Limitations:

The slightest coagulation of the specimen may produce false positive reactive with the FDP plasma.  High levels of rheumatoid factor (RF) may lead to false agglutinations.  Any suspected presence of RF should be confirmed by a separate test for RF. 

The FDP Plasma test is insensitive to heparins up to 2 IU/ml.

The presence of anti-mouse of antibodies in certain subjects may lead to aberrant test results.

Icons & Photos

Collection Instructions

Specimen Collection: Blood

 

Container(s): 3.2% Na Citrate Tube (blue top)

Preferred Volume to Collect: 2.7 mL (full tube)

Minimum Volume to Collect: 1.8 mL (full tube)

Capillary collect ok: No

Microtainer acceptable: No

 

Collection Instructions:

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Platelet Poor Plasma

 

Centrifuge/Spin: Yes

Aliquot: Yes

 

Processing Instructions:

  • Detailed instructions (link): Preparing Platelet Poor Plasma
  • Separate plasma into 1 – 2 aliquots, minimum of 0.5 mL each.
  • Freeze aliquots in plastic transport tubes immediately.

Transport Temperature:

  • Ambient (up to 1 hour in whole blood state)
  • Frozen (plasma only >1 hour)

Rejection Criteria

  • Hemolysis
  • Specimen has been thawed

Specimen Stability

Ambient: 1 hour (8 hours if spun and plasma aliquoted

Frozen: Aliquot plasma for longer storage

Laboratory Retention: 24 hours

Test Frequency

Available 24 hours, TAT 1 day.

Reference Range

<5 µg/mL

Performing Department

COAGULATION

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI
Spectrum Health Blodgett Laboratory, Grand Rapids, MI

Methodology

Rapid latex slide agglutination test using mouse anti-FDP antibodies

CPT

85362

CDM Code

4098415

Epic Test ID

1230100688

LOINC

FDP: 29263-1

Beaker LOINC

FIBRIN DEGREDATION PRODUCTS: 29263-1

Mayo Access Code

SHO10039

Reviewed Date

10/11/2021

Beaker Names

Beaker Procedure Name: FIBRIN SPLIT PRODUCTS
Beaker Display Name: Fibrin Degradation Products (FDP)
BEAKER TEST NAME: FDP
BEAKER TEST REPORT NAME: FDP

Beaker Synonyms

FIBRIN DEGRADATION PRODUCTS

Beaker Location, Container and Temperature

BW COAGULATION: BLUE TOP TUBE
BL COAGULATION: BLUE TOP TUBE