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Epic Code LAB848 Gonadotropin Releasing Hormone (Gn-RH, Luteinizing Hormone-Releasing Hormone LH-RH)

Important Note

Order as Reference Miscellaneous #LAB848; indicate complete test name when ordering.

Additional Codes

Mayo Code: FGNRH

Performing Laboratory

Inter Science Institute

Specimen Type

Serum


Specimen Required


Patient preparation:

Patient should not be on any Steroid, ACTH, Gonadotropin, or Estrogen medications, if possible, for at least 48 hours prior to collection of specimen.

 

Specimen Type: Serum

Container/Tube: Red top or SST

Specimen Volume: 3 mL

Collection Instructions: Draw blood in a plain, red-top tube(s), serum-gel tube(s) is acceptable. Separate immediately and send 3 mL of serum frozen in a plastic vial.


Laboratory Test Directory Note:

COLLECTION NOTE: Volumes listed are in serum or plasma, draw approximately 2 1/2 times the requested volume in whole blood.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 180 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject
Other Specimens other than Serum or Plasma EDTA listed.

Day(s) Performed

Monday through Friday

Reference Values

Adult Reference Range(s):

Males:  4.0 - 8.0 pg/mL

Females:  2.0 - 10.0 pg/mL

 

No pediatric reference ranges available for this test.

Clinical Information

Gonadotropin-Releasing Hormone (Gn-RH), also known as Luteinizing Hormone-Releasing Hormone (LH-RH), is a decapeptide secreted pulsatily from the hypothalamus. It stimulates the release of the Gonadotropins - Luteinizing Hormone and Follicle Stimulating Hormone - exerting a stronger effect on Luteinizing Hormone. Testosterone and Estradiol, whose release is stimulated by the Gonadotropins, exert a negative feedback control on LH-RH both at the hypothalamic site and by decreasing pituitary receptor binding. LH-RH levels are low in patients with hypothalamic hypogonadism differentiating them from the high levels usually found in primary hypopituitary hypogonadism. Accentuation of the LH-RH pulse occurs at the onset of puberty triggering the release of LH and FSH required in pubertal development. LH-RH is stimulated by Epinephrine and suppressed by Dopamine and opiates. LH-RH and some of its agonists are frequently used to induce ovulation.  

Reporting Name

Gonadotropin Releasing Hormone

Method Name

Direct Radioimmunoassay

CPT Code Information

83727

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FGNRH Gonadotropin Releasing Hormone 13660-6

 

Result ID Test Result Name Result LOINC Value
Z0929 Gonadotropin Releasing Hormone 13660-6

Report Available

7 to 11 days

Test Classification

This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.

Clinical Reference

1. J Schopohl, G Mehltretter, R von Zumbusch, T Eversmann, and L von Werder. Comparison of Gonadotropin-Releasing Hormone and Gonadotropin Therapy in Male Patients with Idiopathic Hypogonadism.  Fertility and Sterility 56: 1143-1150, 1991.

2. CB Lambalk, J Schoemaker, GP van Rees, J de Koning, and HAMJ van Dieten. Exogenous versus Endogenous Pulses of Luteinizing Hormone-Releasing Hormone and Secretory Patterns of Gonadotropins. Fertility and Sterility 56: 446-452, 1991.