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Test Code LAB1230573 Monoclonal Gammopathy Screen

Important Note

This test is not available. Tentative go-live December 5th.

Test Name Alias

Protein Electrophoresis IFE if Indicated | SPEP | Immunofixation | Kappa and Lambda serum free light chains

Clinical Information

The Monoclonal Gammopathy Screen reflects expert recommendations for the first line testing for monoclonal gammopathies (plasma cell proliferative disorders).  If amyloidosis (AL) is suspected, first line testing should also include Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB2111444).

Collection Instructions

Specimen Collection: Blood

Container(s): Gold Top (Serum Separator-SST Gel)

Preferred Volume to Collect: 5.0 mL

Minimum Volume to Collect: 2.0 mL

Neonate Volume to Collect: 2.0 mL

Capillary collect ok: Yes

Microtainer acceptable: Yes

Collection Instructions:

  • Fasting specimen preferred.
  • Gently invert gold tube(s) 8 - 10 times to mix clot activator with blood.
  • Specimen should be processed within 2 hours – See Processing Instructions.
  • Protein Electrophoresis cannot be ordered a second time within a 2 week window in Laboratory Information System (LIS)

Processing Instructions (Laboratory, Outpatient or Off-site collection)

Processed Specimen: Serum

Centrifuge/Spin: Yes

Aliquot: No

Processing Instructions:

  • Allow blood to clot for 30 minutes in a vertical position and centrifuge within 2 hours.

Transport Temperature: Refrigerate

Rejection Criteria

  • Specimen not processed within 2 hours
  • Protein Electrophoresis cannot be ordered a second time within a 2 week window in the Laboratory Information System (LIS)

Specimen Stability

Ambient: 8 hours

Refrigerate: 7 days

Laboratory Retention: 7 days

Reflex Information

Reflex approved by Medical Executive Committee. Please see link: Reflex Testing Document

Test Frequency

Kappa and Lambda Free Light Chains: Monday, Wednesday, Friday

Protein Electrophoresis, Serum, IFE if Indicated: Monday through Friday

Turn-around time: 5 days

Reference Range

Kappa and Lambda Free Light Chains

Kappa Free Light Chain: ≥18 Years: 0.33 – 1.94 mg/dL

Lambda Free Light Chain: ≥18 Years: 0.57 – 2.63 mg/dL

Kappa Lambda FLC Ratio: ≥18 Years: 0.26 – 1.65 mg/dL

 

Serum Protein Electrophoresis

Total Protein

0 up to 8 Days: 4.5 – 7.0 g/dL

8 Days up to 3 Years: 5.5 – 7.5 g/dL

>3 Years: 6.0 – 8.0 g/dL

Protein Fractions

Albumin: 3.7 – 4.9 g/dL

Alpha 1 Globulin: 0.2 – 0.4 g/dL

Alpha 2 Globulin: 0.5 – 0.9 g/dL

Beta Globulin: 0.6 – 1.0 g/dL

Gamma Globulin: 0.6 – 1.4 g/dL

Performing Department

IMMUNOCHEMISTRY

Performing Department Laboratory Location

Spectrum Health Regional Laboratory, Grand Rapids, MI

Methodology

See individual tests for Methodology

CPT

83883 x2

84165

Professional fee for Pathologist Interpretation

CDM Code

Unavailable

Epic Test ID

Unavailable

Interface Order Alias

1230573

Mayo Access Code

Unknown

LOINC

Unknown

Reviewed Date

Under review